Twenty-Four–Hour Bence-Jones Protein Determinations: Can We Ensure Accuracy?
نویسندگان
چکیده
منابع مشابه
What's in a name? Bence Jones protein
Plasma cell disorders are important in the differential diagnosis of acute kidney injury and of renal impairment with proteinuria. One or more of several mechanisms can be involved, such as cast nephropathy, deposition of monoclonal immunoglobulins, formation of amyloid fibrils, hypercalcaemia, hyperuricaemia and a variety of tubular syndromes. Various tests, such as serum electrophoresis and i...
متن کاملThe Fate of Injected Bence Jones Protein
Bence Jones protein injected into rabbits was excreted rapidly into the urine. The excreted protein retained the physicochemical and immunochemical properties of the injected Bence Jones protein. In spite of the rapid excretion, a significant portion of the injected Bence Jones protein was found to be metabolized. After reinjection of radioactive Bence Jones protein into the donor patient, only...
متن کاملBence Jones protein in primary systemic amyloidosis.
The recent population-based study by Kyle et al,’ which was the first to provide precise epidemiologic information about primary systemic amyloidosis, reported the demonstration of a monoclonal (M)protein in the serum or urine from 16 of 21 patients (76%) with amyloid of unequivocal Ig origin (AL). However, the number of patients in whom free monoclonal Ig light chain (ie, Bence Jones [BJ] prot...
متن کاملOn what we can ensure
The Conjunction Principle says, roughly, that if the truth of a conjunction can be brought about, then the truth of each conjunct can be brought about. The current essay argues that this principle is not valid. After a clarification of the principle, it is shown how a proper understanding of the involved notions falsify the principle. As a corollary, a recent attack on van Inwagen’s Consequence...
متن کاملMetabolism of Bence Jones Proteins.
Bence Jones proteins are molecules of about 40,000 mol wt present in the urine of many patients with plasma cell malignancy. These microglobulins, which are synthesized in plasma-cell tumors (1, 2), share many immunochemical and physicochemical features with the larger 6.6 S y-globulins. That Bence Jones proteins are similar to or identical with components of the larger y-globulins has been sug...
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ژورنال
عنوان ژورنال: Archives of Pathology & Laboratory Medicine
سال: 2011
ISSN: 0003-9985,1543-2165
DOI: 10.5858/2010-0547-oar